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Sunday, October 27, 2013
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Prevalence of household gun ownership linked to child gun shot wounds
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PUBLIC RELEASE DATE: 27-Oct-2013
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American Academy of Pediatrics
Reducing the number of household firearms, especially handguns, may reduce childhood gunshot injuries
ORLANDO, Fla. There are approximately 7,500 child hospitalizations and 500 in-hospital deaths each year due to injuries sustained from guns. In an abstract presented Oct. 27 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando, researchers also identified a link between the percentage of homes with guns and the prevalence of child gunshot injuries.
In "United States Gunshot ViolenceDisturbing Trends," researchers reviewed statistics from the Kids' Inpatient Database (KID) from 1997, 2000, 2003, 2006 and 2009 (for a total of 36 million pediatric hospital admissions), and estimated state household gun ownership using the most recent Behavioral Risk Factor Surveillance System data (2004).
The study found that approximately 7,500 children are admitted to the hospital for the treatment of injuries sustained from guns each year, and more than 500 children die during hospital admission from these injuries. Between 1997 and 2009, hospitalizations from gunshot wounds increased from 4,270 to 7,730, and in-hospital deaths from 317 to 503.
The study also found a significant association between the percentage of gunshot wounds occurring in the home and the percentage of households containing any firearms, loaded firearms and unlocked loaded firearms.
"Handguns account for the majority of childhood gunshot wounds and this number appears to be increasing over the last decade," said lead study author Arin L. Madenci, MD, MPH. "Furthermore, states with higher percentages of household firearm ownership also tended to have higher proportions of childhood gunshot wounds, especially those occurring in the home."
Many current gun control efforts focus on limiting the availability of military-style semi-automatic assault rifles.
"Policies designed to reduce the number of household firearms, especially handguns, may more effectively reduce the number of gunshot injuries in children," said Dr. Madenci.
###
The American Academy of Pediatrics is an organization of 60,000 primary care pediatricians, pediatric medical subspecialists and pediatric surgical specialists dedicated to the health, safety and well being of infants, children, adolescents and young adults. For more information, visit http://www.aap.org.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
PUBLIC RELEASE DATE: 27-Oct-2013
[
]
ShareContact: Debbie Jacobson
djacobson@aap.org
847-434-7084
American Academy of Pediatrics
Reducing the number of household firearms, especially handguns, may reduce childhood gunshot injuries
ORLANDO, Fla. There are approximately 7,500 child hospitalizations and 500 in-hospital deaths each year due to injuries sustained from guns. In an abstract presented Oct. 27 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando, researchers also identified a link between the percentage of homes with guns and the prevalence of child gunshot injuries.
In "United States Gunshot ViolenceDisturbing Trends," researchers reviewed statistics from the Kids' Inpatient Database (KID) from 1997, 2000, 2003, 2006 and 2009 (for a total of 36 million pediatric hospital admissions), and estimated state household gun ownership using the most recent Behavioral Risk Factor Surveillance System data (2004).
The study found that approximately 7,500 children are admitted to the hospital for the treatment of injuries sustained from guns each year, and more than 500 children die during hospital admission from these injuries. Between 1997 and 2009, hospitalizations from gunshot wounds increased from 4,270 to 7,730, and in-hospital deaths from 317 to 503.
The study also found a significant association between the percentage of gunshot wounds occurring in the home and the percentage of households containing any firearms, loaded firearms and unlocked loaded firearms.
"Handguns account for the majority of childhood gunshot wounds and this number appears to be increasing over the last decade," said lead study author Arin L. Madenci, MD, MPH. "Furthermore, states with higher percentages of household firearm ownership also tended to have higher proportions of childhood gunshot wounds, especially those occurring in the home."
Many current gun control efforts focus on limiting the availability of military-style semi-automatic assault rifles.
"Policies designed to reduce the number of household firearms, especially handguns, may more effectively reduce the number of gunshot injuries in children," said Dr. Madenci.
###
The American Academy of Pediatrics is an organization of 60,000 primary care pediatricians, pediatric medical subspecialists and pediatric surgical specialists dedicated to the health, safety and well being of infants, children, adolescents and young adults. For more information, visit http://www.aap.org.
[
Share]
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-10/aaop-poh101713.php
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Builders of Obama's health website saw red flags
WASHINGTON (AP) — Crammed into conference rooms with pizza for dinner, some programmers building the Obama administration's showcase health insurance website were growing increasingly stressed. Some worked past 10 p.m., energy drinks in hand. Others rewrote computer code over and over to meet what they considered last-minute requests for changes from the government or other contractors.
As questions mount over the website's failure, insider interviews and a review of technical specifications by The Associated Press found a mind-numbingly complex system put together by harried programmers who pushed out a final product that congressional investigators said was tested by the government and not private developers with more expertise.
Meanwhile, the White House said that President Barack Obama's longtime adviser Jeffrey Zients will provide management advice to help fix the system. White House press secretary Jay Carney says Zients will be on a short-term assignment at the Health and Human Services Department before he's due to take over as director of Obama's National Economic Council Jan. 1.
Carney cited Zients' expertise as a longtime management consultant and his "proven track record" since coming to the White House in 2009, both as interim budget director and as chief performance officer, when he headed an effort to streamline government and cut costs. "We're engaged in an all-out effort to improve the online experience," Carney said.
This is not the first time Obama has turned to Zients for help solving a major problem. In the 2009, after far more drivers than anticipated signed up for the Cash for Clunkers program that promised rebates to people who traded in their old cars for more fuel-efficient vehicles, Obama assigned Zients, his deputy budget director at the time, to help eliminate the backlog.
When the same thing happened with sign-ups for an updated version of the GI Bill, one designed to help the 9/11 generation of veterans get a college education, Obama again turned to Zients.
"He's not going to be looking under the hood and tell you 'I can fix the coding, I can fix it,'" Kenneth Baer, who was a senior adviser to Zients at the budget office, said of Zients' newest assignment. "His skill is going to be how to identify challenges, prioritize what solutions need to be done next, assessing what talent is already available and then how to motivate them to do that job as quickly and as ably as possible."
Aneesh Chopra, who was Obama's chief technology officer, said Zients is extremely skilled in figuring things out from a management perspective.
"If I was confident this issue would be resolved before his participation, I am doubly so now," said Chopra, who also worked with Zients at the Advisory Board Co., one of two business advisory firms where Zients held top posts. "Jeff's track record is really a relentless focus on execution."
Health and Human Services Secretary Kathleen Sebelius said in a post on HealthCare.gov that her agency is also bringing in more experts and specialists from government and industry, including top Silicon Valley companies.
"This new infusion of talent will bring a powerful array of subject matter expertise and skills, including extensive experience scaling major IT systems," she said. "This effort is being marshaled as part of a cross-functional team that is working aggressively to diagnose parts of HealthCare.gov that are experiencing problems, learn from successful states, prioritize issues, and fix them."
Project developers for the health care website who spoke to the AP on condition of anonymity — because they feared they would otherwise be fired — said they raised doubts among themselves whether the website could be ready in time. They complained openly to each other about what they considered tight and unrealistic deadlines. One was nearly brought to tears over the stress of finishing on time, one developer said. Website builders saw red flags for months.
A review of internal architectural diagrams obtained by the AP revealed the system's complexity. Insurance applicants have a host of personal information verified, including income and immigration status. The system connects to other federal computer networks, including ones at the Social Security Administration, IRS, Veterans Administration, Office of Personnel Management and the Peace Corps.
Obama on Monday acknowledged technical problems that he described as "kinks in the system." But in remarks at a Rose Garden event, Obama offered no explanation for the failure except to note that high traffic to the website caused some of the slowdowns. He said it had been visited nearly 20 million times — fewer monthly visits so far than many commercial websites, such as PayPal, AOL, Wikipedia or Pinterest.
"The problem has been that the website that's supposed to make it easy to apply for and purchase the insurance is not working the way it should for everybody," Obama said. "There's no sugarcoating it. The website has been too slow. People have been getting stuck during the application process. And I think it's fair to say that nobody is more frustrated by that than I am."
The online system was envisioned as a simple way for people without health insurance to comparison-shop among competing plans offered in their state, pick their preferred level of coverage and cost and sign up. For many, it's not worked out that way so far.
Just weeks before the launch of HealthCare.gov on Oct. 1, one programmer said, colleagues huddled in conference rooms trying to patch "bugs," or deficiencies in computer code. Unresolved problems led to visitors experiencing cryptic error messages or enduring long waits trying to sign up.
Congressional investigators have concluded that the government's Centers for Medicare and Medicaid Services, not private software developers, tested the exchange's computer systems during the final weeks. That task, known as integration testing, is usually handled by software companies because it ferrets out problems before the public sees the final product.
The government spent at least $394 million in contracts to build the federal health care exchange and the data hub. Those contracts included major awards to Virginia-based CGI Federal Inc., Maryland-based Quality Software Services Inc. and Booz Allen Hamilton Inc.
CGI Federal said in a statement Monday it was working with the government and other contractors "around the clock" to improve the system, which it called "complex, ambitious and unprecedented."
The schematics from late 2012 show how officials designated a "data services hub" — a traffic cop for managing information — in lieu of a design that would have allowed state exchanges to connect directly to government servers when verifying an applicant's information. On Sunday, the Health and Human Services Department said the data hub was working but not meeting public expectations: "We are committed to doing better."
Administration officials so far have refused to say how many people actually have managed to enroll in insurance during the three weeks since the new marketplaces became available. Without enrollment numbers, it's impossible to know whether the program is on track to reach projections from the Congressional Budget Office that 7 million people would gain coverage during the first year the exchanges were available.
Instead, officials have selectively cited figures that put the insurance exchanges in a positive light. They say more than 19 million people have logged on to the federal website and nearly 500,000 have filled out applications for insurance through both the federal and state-run sites.
The flood of computer problems since the website went online has been deeply embarrassing for the White House. The snags have called into question whether the administration is capable of implementing the complex policy and why senior administration officials — including the president — appear to have been unaware of the scope of the problems when the exchange sites opened.
Even as the president spoke at the Rose Garden, more problems were coming to light. The administration acknowledged that a planned upgrade to the website had been postponed indefinitely and that online Spanish-language signups would remain unavailable, despite a promise to Hispanic groups that the capability would start this week. And the government tweaked the website's home page so visitors can now view phone numbers to apply the old-fashioned way or window-shop for insurance rates without registering first.
The House Energy and Commerce Committee was expected to conduct an oversight hearing Thursday, probably without Sebelius testifying. She could testify on Capitol Hill on the subject as early as next week.
Uninsured Americans have until about mid-February to sign up for coverage if they are to meet the law's requirement that they be insured by the end of March. If they don't, they will face a penalty. The administration says it's working to address the timing issue to provide more flexibility.
Sen. Marco Rubio, R-Fla., plans to introduce legislation to delay that requirement because: "It's not fair to punish people for not buying something that's not available," Rubio told "CBS This Morning" on Tuesday.
Citing the website problems, Sen. Jeanne Shaheen, D-N.H., also urged the White House to extend the open enrollment period past March 31, 2014.
In a letter Tuesday to Obama, Shaheen suggested extending open enrollment to "provide greater flexibility for the American people seeking to access health insurance," according to an emailed statement from her office. Shaheen also asked the White House to clarify how the "individual responsibility penalty will be administered and enforced" in light of the website's difficulties.
On Monday, the White House advised people frustrated by the online tangle that they can enroll by calling 1-800-318-2596 in a process that should take 25 minutes for an individual or 45 minutes for a family. Assistance is also available in communities from helpers who can be found at LocalHelp.HealthCare.gov.
___
Associated Press writers Ricardo Alonso-Zaldivar and Darlene Superville contributed to this report.
___
Follow Jack Gillum on Twitter at http://twitter.com/jackgillum or Julie Pace at http://twitter.com/jpaceDC.
- Politics & Government
- Government
- Obama
- White House
- health insurance
- Jeffrey Zients
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Seth Meyers & Alexi Ashe’s Wedding Day: Vogue Has Pics!
He couldn’t have been happier to say “I Do” with his beautiful bride Alexi Ashe, and Seth Meyers' wedding day has been captured in gorgeous photos thanks to Vogue magazine.
The “Saturday Night Live” stud and his wife took the plunge at Martha’s Vineyard in Massachusetts on September 1st, and they both sported ear-to-ear grins the entire time.
Of course, Alexi selected a magnificent Caroline Herrera cap-sleeve lace gown teamed with an elegant veil and simple drop earrings, while Seth selected a classy dark suit.
As for the celebrity-laden guest list, stars like Brad Paisley, Olivia Wilde, Jack McBrayer, Ali Larter, Rashida Jones, Nick Kroll, Kristen Wiig, and Jimmy Fallon all showed up for the shindig.
Source: http://celebrity-gossip.net/seth-meyers/seth-meyers-alexi-ashe%E2%80%99s-wedding-day-vogue-has-pics-948998
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Bipartisan Anger, Competing Interests Over HealthCare.gov
With the drama of the 17-day government shutdown over, the spotlight this week turned to the troubled rollout of the federal health insurance exchanges. Host Scott Simon talks to NPR's Ron Elving about the frustrations from both parties over the crippled HealthCare.gov website.
Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.
SCOTT SIMON, HOST:
This is WEEKEND EDITION from NPR News. I'm Scott Simon. With the drama of the 17-day government shutdown over, the spotlight returned this week to the troubled rollout of the Obamacare insurance exchanges. Both Republicans and Democrats expressed anger over the crippled HealthCare.gov website during hearings that were conducted this week, but of course there are competing agendas, as there always are.
To help us sort through these political implications is our own Ron Elving, senior Washington editor. Ron, thanks very much for being with us.
RON ELVING, BYLINE: Good to be with you, Scott.
SIMON: How big a deal might these problems be?
ELVING: It's a big deal because, you know, it casts doubt on the basic practical viability of what has been the President's signature legislative achievement, the Affordable Care Act. And just at the moment when it had survived all of these other big political tests, you know, passage and enactment and the Supreme Court test, and then the big shutdown showdown, just when we get through all of those traps, well, how ironic that a faulty website could seemingly be the undoing of Obamacare at this point.
SIMON: Politically speaking, is this the kind of thing that can be fixed and move on, or could there be something more permanent here?
ELVING: Well, we just had a briefing from the former director of the Office of Management and Budget who is a very well-respected crisis manager, Jeff Zients, and the President has brought him in and put him in charge of trying to straighten all of this out. And he says, look, we've had 700,000 people create accounts on these websites in the first couple, three weeks, troubled as they have been. Problem is, of course, only a minor fraction of those people have actually managed to get through to enrolling for health insurance, private health insurance.
About half the people who've gotten through got through on state exchanges, as opposed to the federal ones that most of the states essentially defaulted to. So the program is unquestionably troubled. But if it is possible to bring it around, and Jeff Zients says by the end of November - give us four or five weeks - the vast majority of people, he says, will have a smooth experience when they go to HealthCare.gov.
If that's true then the Obama Administration will have a reason for thanksgiving.
SIMON: With the advantage of a few days hindsight, did Republican critics of the program miss an opportunity during the shutdown to be able to talk about this?
ELVING: Surely if there had been no shutdown crisis, the first days in October when this site was struggling would have been the biggest story, the only story in Washington. Instead, they were overshadowed by this other crisis. So now that we're through the woods on the one hand, we suddenly have this focus on the health care site, then that's an opportunity for the Republicans really to make a comeback, although they have to be kicking themselves that they weren't able to do this right from the beginning.
And right now they're trying to make up lost ground on that and we'll have to see in the weeks ahead which way this goes. Is there more resentment over the shutdown crisis? Is there more of a lingering bruise on their brand from that? Or are people still focused week after week on the inadequacies of this particular website?
SIMON: NPR's Ron Elving. Thanks so much.
ELVING: Thank you, Scott.
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NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.
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Saturday, October 26, 2013
Wall St. gains on Fed hopes; Amazon.com up after the bell
By Caroline Valetkevitch
NEW YORK (Reuters) - Stocks resumed their upward move on Thursday as economic data underscored views U.S. monetary stimulus will be in place for the foreseeable future and as earnings offered some upbeat news.
Shares of PulteGroup Inc
Economic data showed initial claims for state unemployment benefits fell less than expected in the latest week, though analysts noted a backlog of applications in California. On Tuesday, data showed that employers added fewer jobs than expected in September.
The day's data also included a preliminary look at Markit's October Manufacturing Purchasing Managers Index, which grew at its slowest pace in a year while factory output contracted for the first time since late 2009.
Expectations the Fed will continue its stimulus have helped stocks all year, with the S&P 500 index up 22.8 percent so far for 2013.
The S&P 500 declined on Wednesday, ending its four-session streak of record high finishes. Last week's legislation to avoid a debt default and end a partial government shutdown gave way to a relief rally and speculation that the Federal Reserve will delay scaling back its stimulus for several months.
"You've got this underlying liquidity surge that's propping prices up, and earnings season hasn't been poor," said Bucky Hellwig, senior vice president at BB&T Wealth Management in Birmingham, Alabama.
The Dow Jones industrial average <.dji> was up 95.88 points, or 0.62 percent, at 15,509.21. The Standard & Poor's 500 Index <.spx> was up 5.69 points, or 0.33 percent, at 1,752.07. The Nasdaq Composite Index <.ixic> was up 21.89 points, or 0.56 percent, at 3,928.96.
After the bell, Twitter
Ford
Also on the rise were Apple shares , up 1.3 percent at $531.91, after investor Carl Icahn, in a public letter to Apple Chief Executive Tim Cook, called on Apple to commence a $150 billion share buyback immediately.
Third-quarter earnings overall has had its disappointments, including some weak outlooks and just 53 percent of companies so far beating analysts' revenue expectations, below the long-term average of 61 percent, according to Thomson Reuters data.
About 68 percent of companies are beating analysts' earnings expectations, above the 63 percent long-term average.
Among the day's decliners were Dow Chemical Co
AT&T, a Dow component, fell 1.8 percent to $34.63 while Dow Chemical lost 1 percent to $40.62. Xerox slumped 10.4 percent to $9.61 after a weak outlook.
Shares of Symantec Corp
Also after the bell, shares of both Amazon.com and Microsoft
Shares of Microsoft rose 5.6 percent to $35.60 after its profit rose more than expected.
DuPont
(Editing by Nick Zieminski and Kenneth Barry)
- Finance
- Investment & Company Information
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Early-life exposure of frogs to herbicide increases mortality from fungal disease
PUBLIC RELEASE DATE: 23-Oct-2013
[
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ShareContact: Vickie Chachere
vchachere@usf.edu
813-974-6251
University of South Florida (USF Health)
The combination of the herbicide atrazine and a fungal disease is particularly deadly to frogs, shows new research from a University of South Florida laboratory, which has been investigating the global demise of amphibian populations.
USF Biologist Jason Rohr said the new findings show that early-life exposure to atrazine increases frog mortality but only when the frogs were challenged with a chytrid fungus, a pathogen implicated in worldwide amphibian declines. The research is published in the new edition of Proceedings of the Royal Society B.
"Understanding how stressors cause enduring health effects is important because these stressors might then be avoided or mitigated during formative developmental stages to prevent lasting increases in disease susceptibility," Rohr said.
The study was conducted by Rohr and Lynn Martin, Associate Professors of USF's Department of Integrative Biology; USF researchers Taegan McMahon and Neal Halstead; and colleagues at the University of Florida, Oakland University, and Archbold Biological Station.
Their experiments showed that a six-day exposure to environmentally relevant concentrations of atrazine, one of the most common herbicides in the world, increased frog mortality 46 days after the atrazine exposure, but only when frogs were challenged with the chytrid fungus. This increase in mortality was driven by a reduction in the frogs' tolerance of the infection.
Moreover, the researchers found no evidence of recovery from the atrazine exposure and the atrazine-induced increase in disease susceptibility was independent of when the atrazine exposure occurred during tadpole development.
"These findings are important because they suggest that amphibians might need to be exposed only to atrazine briefly as larvae for atrazine to cause persistent increases in their risk of chytri-induced mortality," Rohr said. "Our findings suggest that reducing early-life exposure of amphibians to atrazine could reduce lasting increases in the risk of mortality from a disease associated with worldwide amphibian declines."
Until this study, scientists knew little about how early-life exposure to stressors affected the risk of infectious diseases for amphibians later in life.
"Identifying which, when, and how stressors cause enduring effects on disease risk could facilitate disease prevention in wildlife and humans, an approach that is often more cost-effective and efficient than reactive medicine," Rohr said.
The findings are also the latest chapter in research Rohr and his lab has conducted on the impact of atrazine on amphibians. These findings are consistent with earlier studies that concluded that, while the chemical typically does not directly kill amphibians and fish, there is consistent scientific evidence that it negatively impacts their biology by affecting their growth and immune and endocrine systems.
###
Read the full text of the research article here.
The University of South Florida is a high-impact, global research university dedicated to student success. USF ranks 50th in the nation for federal expenditures in research and total expenditures in research among all U.S. universities, public or private, according to the National Science Foundation. Serving more than 47,000 students, the USF System has an annual budget of $1.5 billion and an annual economic impact of $3.7 billion. USF is a member of the American Athletic Conference.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
PUBLIC RELEASE DATE: 23-Oct-2013
[
]
ShareContact: Vickie Chachere
vchachere@usf.edu
813-974-6251
University of South Florida (USF Health)
The combination of the herbicide atrazine and a fungal disease is particularly deadly to frogs, shows new research from a University of South Florida laboratory, which has been investigating the global demise of amphibian populations.
USF Biologist Jason Rohr said the new findings show that early-life exposure to atrazine increases frog mortality but only when the frogs were challenged with a chytrid fungus, a pathogen implicated in worldwide amphibian declines. The research is published in the new edition of Proceedings of the Royal Society B.
"Understanding how stressors cause enduring health effects is important because these stressors might then be avoided or mitigated during formative developmental stages to prevent lasting increases in disease susceptibility," Rohr said.
The study was conducted by Rohr and Lynn Martin, Associate Professors of USF's Department of Integrative Biology; USF researchers Taegan McMahon and Neal Halstead; and colleagues at the University of Florida, Oakland University, and Archbold Biological Station.
Their experiments showed that a six-day exposure to environmentally relevant concentrations of atrazine, one of the most common herbicides in the world, increased frog mortality 46 days after the atrazine exposure, but only when frogs were challenged with the chytrid fungus. This increase in mortality was driven by a reduction in the frogs' tolerance of the infection.
Moreover, the researchers found no evidence of recovery from the atrazine exposure and the atrazine-induced increase in disease susceptibility was independent of when the atrazine exposure occurred during tadpole development.
"These findings are important because they suggest that amphibians might need to be exposed only to atrazine briefly as larvae for atrazine to cause persistent increases in their risk of chytri-induced mortality," Rohr said. "Our findings suggest that reducing early-life exposure of amphibians to atrazine could reduce lasting increases in the risk of mortality from a disease associated with worldwide amphibian declines."
Until this study, scientists knew little about how early-life exposure to stressors affected the risk of infectious diseases for amphibians later in life.
"Identifying which, when, and how stressors cause enduring effects on disease risk could facilitate disease prevention in wildlife and humans, an approach that is often more cost-effective and efficient than reactive medicine," Rohr said.
The findings are also the latest chapter in research Rohr and his lab has conducted on the impact of atrazine on amphibians. These findings are consistent with earlier studies that concluded that, while the chemical typically does not directly kill amphibians and fish, there is consistent scientific evidence that it negatively impacts their biology by affecting their growth and immune and endocrine systems.
###
Read the full text of the research article here.
The University of South Florida is a high-impact, global research university dedicated to student success. USF ranks 50th in the nation for federal expenditures in research and total expenditures in research among all U.S. universities, public or private, according to the National Science Foundation. Serving more than 47,000 students, the USF System has an annual budget of $1.5 billion and an annual economic impact of $3.7 billion. USF is a member of the American Athletic Conference.
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Source: http://www.eurekalert.org/pub_releases/2013-10/uosf-eeo102313.php
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Rheumatoid arthritis and heart disease: Mayo Clinic studies shed light on dangerous connection
PUBLIC RELEASE DATE: 26-Oct-2013
[
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ShareContact: Sharon Theimer
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Early menopause is risk factor, research presented at American College of Rheumatology meeting shows
SAN DIEGO -- People with rheumatoid arthritis and other chronic inflammatory conditions are at higher risk of heart disease. Who is in the most danger, why and how best to prevent and detect cardiovascular complications are important questions for physicians and researchers. Mayo Clinic studies presented at the American College of Rheumatology annual meeting shed new light on this connection, in part by revealing factors that seem to put some rheumatoid arthritis patients in greater jeopardy of heart problems: early menopause, more severe rheumatoid arthritis and immunity to a common virus, cytomegalovirus, among others.
MULTIMEDIA ALERT: Video of Dr. Matteson is available for download from the Mayo Clinic News Network.
In one study, Mayo researchers discovered that patients whose rheumatoid arthritis is more severe are likelier to have heart problems. That becomes true soon after rheumatoid arthritis strikes, making early treatment of rheumatoid arthritis important, says co-author Eric Matteson, M.D., chair of rheumatology at Mayo Clinic in Rochester, Minn.
"One thing that we learned in particular in this study is that the high disease burden on the joints in the first year of disease already is a very strong predictor of cardiovascular disease subsequently, and that seems to be mitigated as time goes on if the disease burden can be reduced too," Dr. Matteson says.
In other research, a Mayo team looked at a common virus called cytomegalovirus, a bug many people get and do not even know they have. They found correlations between rheumatoid arthritis patients' immune response to the virus and the development of myocardial disease.
If it turns out that there is this relationship, then it may be that one way to spot patients who are at higher risk for heart disease would be an immune profile or biomarkers related to the cytomegalovirus and its associated immune activation signaling," says Dr. Matteson, a co-author.
Another study found that women with rheumatoid arthritis and early menopause -- menopause before age 45 -- also seem to be at higher risk of heart disease. About two-thirds of patients with rheumatoid
arthritis are women, and researchers have long studied possible hormonal influences on development of the disease, Dr. Matteson says.
"This study shows the complex relationship between rheumatoid arthritis, hormones and heart disease," says Dr. Matteson, the senior author. "We also found patients who have had multiple children, especially seven or more, are at higher risk of cardiovascular disease compared with women who have menopause at a normal age or have fewer children."
Other Mayo Clinic studies found:
- A higher incidence of the heart rhythm disorder, prolonged QT interval, in rheumatoid arthritis patients, particularly those who had a higher "sed rate" -- a blood test that can reveal inflammatory activity when their rheumatoid arthritis was diagnosed.
- Rheumatoid arthritis patients are likelier to develop a high uric acid level, a condition called hyperuricemia, and that is a significant predictor of peripheral arterial disease, but doesn't appear to be one for cardiovascular disease.
- Multiple risk factors for heart disease were spotted in patients when they were diagnosed with giant cell arteritis, inflammation of the lining of the arteries. However, giant cell arteritis patients do not seem to be at higher risk of acute coronary syndrome, a condition whose symptoms mirror those of a heart attack.
###
To interview Dr. Matteson or other Mayo Clinic researchers about these studies or for expert comment on other research being presented at the ACR meeting, please contact Sharon Theimer in Mayo Clinic Public Affairs at 507-284-5005 or newsbureau@mayo.edu.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and http://www.mayoclinic.org/news.
Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.
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PUBLIC RELEASE DATE: 26-Oct-2013
[
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Mayo Clinic
Early menopause is risk factor, research presented at American College of Rheumatology meeting shows
SAN DIEGO -- People with rheumatoid arthritis and other chronic inflammatory conditions are at higher risk of heart disease. Who is in the most danger, why and how best to prevent and detect cardiovascular complications are important questions for physicians and researchers. Mayo Clinic studies presented at the American College of Rheumatology annual meeting shed new light on this connection, in part by revealing factors that seem to put some rheumatoid arthritis patients in greater jeopardy of heart problems: early menopause, more severe rheumatoid arthritis and immunity to a common virus, cytomegalovirus, among others.
MULTIMEDIA ALERT: Video of Dr. Matteson is available for download from the Mayo Clinic News Network.
In one study, Mayo researchers discovered that patients whose rheumatoid arthritis is more severe are likelier to have heart problems. That becomes true soon after rheumatoid arthritis strikes, making early treatment of rheumatoid arthritis important, says co-author Eric Matteson, M.D., chair of rheumatology at Mayo Clinic in Rochester, Minn.
"One thing that we learned in particular in this study is that the high disease burden on the joints in the first year of disease already is a very strong predictor of cardiovascular disease subsequently, and that seems to be mitigated as time goes on if the disease burden can be reduced too," Dr. Matteson says.
In other research, a Mayo team looked at a common virus called cytomegalovirus, a bug many people get and do not even know they have. They found correlations between rheumatoid arthritis patients' immune response to the virus and the development of myocardial disease.
If it turns out that there is this relationship, then it may be that one way to spot patients who are at higher risk for heart disease would be an immune profile or biomarkers related to the cytomegalovirus and its associated immune activation signaling," says Dr. Matteson, a co-author.
Another study found that women with rheumatoid arthritis and early menopause -- menopause before age 45 -- also seem to be at higher risk of heart disease. About two-thirds of patients with rheumatoid
arthritis are women, and researchers have long studied possible hormonal influences on development of the disease, Dr. Matteson says.
"This study shows the complex relationship between rheumatoid arthritis, hormones and heart disease," says Dr. Matteson, the senior author. "We also found patients who have had multiple children, especially seven or more, are at higher risk of cardiovascular disease compared with women who have menopause at a normal age or have fewer children."
Other Mayo Clinic studies found:
- A higher incidence of the heart rhythm disorder, prolonged QT interval, in rheumatoid arthritis patients, particularly those who had a higher "sed rate" -- a blood test that can reveal inflammatory activity when their rheumatoid arthritis was diagnosed.
- Rheumatoid arthritis patients are likelier to develop a high uric acid level, a condition called hyperuricemia, and that is a significant predictor of peripheral arterial disease, but doesn't appear to be one for cardiovascular disease.
- Multiple risk factors for heart disease were spotted in patients when they were diagnosed with giant cell arteritis, inflammation of the lining of the arteries. However, giant cell arteritis patients do not seem to be at higher risk of acute coronary syndrome, a condition whose symptoms mirror those of a heart attack.
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To interview Dr. Matteson or other Mayo Clinic researchers about these studies or for expert comment on other research being presented at the ACR meeting, please contact Sharon Theimer in Mayo Clinic Public Affairs at 507-284-5005 or newsbureau@mayo.edu.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and http://www.mayoclinic.org/news.
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Source: http://www.eurekalert.org/pub_releases/2013-10/mc-raa102213.php
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Suspect in Northern Calif. standoff surrenders
ROSEVILLE, Calif. (AP) — Some residents of a suburban Sacramento city still were waiting to return to their homes 24 hours after a Friday night shootout between law enforcement agents and a wanted parolee left six officers injured.
Roseville police spokesman Lt. Cal Walstad said that one Roseville police officer with a jaw wound and a federal immigration agent shot in the leg remain hospitalized Saturday in serious condition. Four other Roseville officers injured by shrapnel were treated and released.
The suspect in the violent confrontation that ended after an hours-long standoff is a validated gang member with a criminal record that includes assault and carjacking. Samuel Nathan Duran, 32, was taken to the Placer County jail Saturday after being treated for scrapes and cuts after surrendering just after midnight.
"Last night our community experienced what can happen in any when a violent wanted felon is completely committed to not going back to jail," said Roseville Police Chief Daniel Hahn at a news conference Saturday.
Duran was being held on a parole violation, but Hahn said he expected multiple charges of attempted murder would be added.
State corrections officials told The Associated Press that Duran has a record stretching back to at least 2002, when he was convicted of possessing a controlled substance. In 2009, he was sentenced to four years for assault with a deadly weapon, resisting arrest and attempted carjacking.
Records show he was paroled last in April, but that the parole was revoked in July.
Officers on another mission recognized Duran when they saw him riding a bike Friday at about 3 p.m., the chief said. They recognized him as being wanted for the parole violation.
A federal immigration agent attempted to chase Duran on foot, but was shot in the leg. Officials said Duran was armed with a handgun but wouldn't specify the type.
Duran quickly holed up in a nearby house, and a mother and child inside escaped out a side door.
The incident created scenes of panic and chaos in a typically quiet middle class suburb of about 120,000 that is 20 miles northeast of the state capitol. Walstad described multiple shooting sites as the suspect tried to escape a swarm of descending law enforcement agents, and reporters on the scene described hearing several volleys of gunfire.
As officers attempted to capture the suspect before his surrender, helicopters were circling overhead and armored vehicles and other police cars flocked to the area.
At least 15 homes were evacuated, and the area remained a crime scene late Saturday, Walstad said.
U.S. Immigration and Customs Enforcement spokeswoman Virginia Kice said that agency's officer was stable and in good spirits after being taken to Sutter Roseville Medical Center.
Law enforcement officers had been looking for Duran in the area for at least 10 days before finding him on Friday, Walstad said. When they found him, Walstad added, he opened fire, wounding the federal immigration officer, who was on the scene to provide support for the Roseville police.
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China to send air pollution inspection teams to provinces
BEIJING (Reuters) - China's Environment Ministry said on Thursday it will send inspection teams to provinces and cities most seriously affected by smog to ensure rules on fighting air pollution are being enforced.
Air quality in cities is of increasing concern to China's stability-obsessed leaders, anxious to douse potential unrest as a more affluent urban population turns against a growth-at-all-costs economic model that has poisoned much of the country's air, water and soil.
China's smog crisis was thrown back dramatically into the spotlight this week when Harbin, a frigid northeastern city of 11 million people, virtually ground to a halt when a pollution index showed airborne contaminants at around 50 times the levels recommended by the World Health Organisation.
The problem was partly blamed on the government turning on the heating for the winter. Collective central heating, activated on a date set by the government, provides heat to 65 percent of Harbin, figures quoted last year in the state media show. Much of that heat comes from burning coal. Beijing's central heating normally comes on in mid-November.
China's government has announced many plans to fight pollution over the years but has made little obvious progress, especially in the country's north and northeast, where coal burning has driven the rapid growth in heavy industrial output.
Enforcing rules has been a particular problem with growth-obsessed local governments and powerful state-owned enterprises often ignoring central government guidelines and even falsifying their emissions data.
The Environment Ministry said on its website (www.zhb.gov.cn) that teams would from now until March visit Beijing and its surrounding regions, the Pearl and Yangtze River deltas, Chengdu, Chongqing and Urumqi, all parts of China which have smog problems.
The teams will ensure that factories have installed the correct equipment to cut emissions of sulphur dioxide, that plants previously closed remain shut and that local governments are enforcing clean air policies, the ministry added.
Factories that have particular problems will have environment inspection teams permanently based on site and legal means will be used to punish companies with particular problems, it said.
Regional environment inspection teams who do not do their jobs properly will be prosecuted and the media will be used to name and shame the most egregious examples of pollution, the ministry added.
The public will also be encouraged to report pollution problems to the ministry, it said.
China published a detailed action plan on tackling air pollution in September, saying it would cut coal consumption and ban new industrial projects like power plants and steel mills in key cities and regions such as Beijing and the Yangtze river delta.
Beijing, sometimes derided as "Greyjing" or "Beige-jing" by English-speaking residents, suffered its own smog emergency last winter when the pollution index reached 45 times the recommended level one particularly bad day in January.
Smoke from factories and heating plants, winds from the Gobi Desert and fumes from millions of vehicles can combine to blanket the city in a pungent shroud for days.
(Reporting by Ben Blanchard; Additional reporting by David Stanway; Editing by Matt Driskill)
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Problems remain after Microsoft yanks Windows RT 8.1 update
In case you missed it, late Friday afternoon Microsoft pulled the Windows RT 8.1 update. Enough customers complained about BSODs and completely bricked machines -- including, notably, Microsoft Surface RT machines -- after applying the RT-to-RT 8.1 upgrade, that the update was yanked entirely.
There's also been a steady stream of complaints about the Win8-to-Win8.1 update, including an inability to connect with Remote Access Website connections. Here's an overview of what we know so far has happened, and how you may be able to recover.
Microsoft released the Windows 8.1 upgrade early in the morning (U.S. time) on Oct. 17. For consumers and others who don't have Volume License agreements with Microsoft, the update was directly accessible through the Microsoft Store. Volume Licensees had access through the VLSC. And, of course, MSDN and TechNet members have had access to the Windows 8.1 Enterprise (but not the Windows RT 8.1) bits for a month.
By Oct. 18, many users had reported problems with a Blue Screen, 0xC1900101 - 0x40017 error with the Windows 8.1 update. To date, the Microsoft Answers forum discussion that deals with that specific BSOD is up to 24 pages of comments, and Microsoft hasn't responded with any worthwhile suggestions, much less a solution.
Now we're seeing a second wave of problems.
Windows RT customers (those with retail copies of Windows RT, not volume licensees) encountered unresolved Blue Screen 0xc000000d errors with notification that "Your PC needs to be repaired / The Boot Configuration Data file is missing some required information / File: \BCD". On Oct. 19 -- two days after the update was released -- Microsoft MVP Wesley_P posted on the Answers Forum: "Why isn't the Windows RT 8.1 upgrade available in the Microsoft store?"
Apparently it took Microsoft about 48 hours to pull the upgrade. In a post without a time stamp, on a rather obscure site , Microsoft issued this advisory:
Microsoft is investigating a situation affecting a limited number of users updating their Windows RT devices to Windows RT 8.1. As a result, we have temporarily removed the Windows RT 8.1 update from the Windows Store. We are working to resolve the situation as quickly as possible and apologize for any inconvenience. We will provide updates as they become available.
I have seen no further comment from Microsoft, no acknowledgment or description of the problem, and certainly no fix.
Ozzie Scott Williams, on his technical blog kickthatcomputer ("Annoying stuff I figured out / I really hate computers"), has come up with an ingenious workaround. Big problem: the method requires a USB recovery drive for your Windows RT computer, and few people have one sitting around.
However, following the steps he outlines, if you trust him (disclaimer: I don't know Williams), you can create a Windows RT recovery USB drive. Using the recovery USB drive, there's a way to bring up an old-fashioned command prompt, and type in a one-line command to rebuild the trashed BCD. Once the BCD is fixed, apparently Windows RT 8.1 will boot.
Score one for the DOS command line. Hard to believe it would bring a borked Surface RT back to life.
The other major, solvable Windows 8.1 bug I've seen makes it impossible to connect Internet Explorer to a Remote Web Access website running on a Small Business Server 2011 server. Poster Yves describes it on the TechNet forum:
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Obama: Shutdown exposed clash of political visions
NEW YORK (AP) — Regrouping with Democrats after a bitter budget fight, President Barack Obama on Friday cast the recent spending-and-debt standoff with Congress as "a symptom of a larger challenge" but one offering Democrats the chance to show voters the virtues of their vision for government ahead of the 2014 midterm elections.
At the heart of the impasse that shuttered the government were deep disagreements about what role the government should play in helping Americans succeed, Obama told about 60 donors at a fundraiser for House Democrats.
"The shutdown was about more than just health care," Obama said. "It was about a contrast of visions, about what our obligations are to each other as fellow citizens."
"And we've got the better side of that argument," Obama added.
It was the first glimpse at how Obama and Democrats will seek to frame the crisis in the minds of donors and voters ahead of next year's pivotal midterm elections. Obama put political events on hold during the 16-day shutdown but returned to campaigning for Democrats Friday with a pair of top-dollar events in New York.
Obama told donors that the impasse was "a symptom of a larger challenge," exposing how American politics, with its intense focus on ideology, has become detached from the problems ordinary Americans face. He portrayed the crisis as an opportunity for Democrats to unite behind a vision of broad-based prosperity, where the government has a hand in giving people the tools to succeed.
"We believe that government has a role to play," Obama said.
Democrats emerged strengthened politically from the crisis, in which Republicans refused for weeks to fund the government unless Obama agreed to debilitating changes to his health care law. Polls show more Americans blamed Republicans than Democrats for the dysfunction.
But how effectively Democrats can turn that leverage into gains in an election more than a year out remains an open question.
"The stakes are high," Obama said. "The one thing I'm absolutely confident about is that if we work hard, that we can make a case to the American people and we can win it."
Although Democrats remained remarkably united during the crisis, Obama acknowledged that members of his party hold a range of views on key issues heading into 2014. But he said they agree on their vision of the U.S. as a place where opportunity and prosperity are broad-based and available to all.
"It's not always pleasant for me and Nancy, but it's healthy," Obama said, referring to House Democratic leader Nancy Pelosi, who joined Obama at the fundraiser in a glitzy Manhattan home.
The New York swing kicked off an intense, six-week burst of fundraising for Obama, who will headline at least nine fundraisers from Florida to Texas to California before the end of November for Democratic campaign committees. Michelle Obama and Vice President Joe Biden are holding their own events.
Ahead of the fundraisers, Obama made a surprise stop at a landmark Brooklyn eatery with Bill de Blasio, the Democratic candidate in New York's upcoming mayoral election. Obama, who has endorsed de Blasio, went table to table shaking hands and posing for photos, evoking images of similar campaign stops during Obama's two presidential campaigns.
Obama also toured a Brooklyn high school to showcase a rare program that lets students finish high school with an associate's degree in computers or engineering. A school gymnasium as his backdrop, Obama framed the budget talks set to resume next week by urging Congress to put more money into education and other programs he said lead to growth.
"Don't tell me we can afford to shut down the government, which costs our economy billions of dollars, but we can't afford to invest in our education systems," Obama said.
The political blow to the GOP from the crisis has made some Democrats more bullish about retaking the House next year - a tall order that, if successful, would bolster Obama's prospects for achieving sweeping second-term goals that Republicans refuse to consider.
But at the same time, Obama is weighed down by the calamitous debut of the website for new insurance exchanges, raising the prospect that Obama's health care law will be more of a liability than an asset in 2014 even for Democrats who supported the law.
Obama made no mention of the website or its ongoing issues in his remarks to donors Friday.
"I would take our position over theirs any day of the week," said Mo Elleithee, the Democratic National Committee's communications director. "We have been working to give people more benefits and increase their access to affordable health care, while Republicans shut down the government."
Traditionally, the president is a party's most potent fundraising tool. But Republicans say that's where Obama's usefulness to his party ends. After all, the health insurance program remains a tough sell even with independent voters, and Obama is personally unpopular in many of the Southern, conservative-leaning states holding critical Senate elections next year.
"There's still not one Democrat candidate in a toss-up race who wants him visiting their district, because they know he's not wanted anywhere other than New York, San Francisco or Chicago," said Daniel Scarpinato, a National Republican Congressional Committee official.
___
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Associated PressSource: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-10-26-Obama/id-b60f876d62dd4d75910b6f594275f39cRelated Topics: glee obama speech meteor shower dairy queen Huntington Beach riot
Rossi, Roma top AP weekly soccer poll
Fiorentina's Giuseppe Rossi celebrates after scoring during a Serie A soccer match between Fiorentina and Juventus at the Artemio Franchi stadium in Florence, Italy, Sunday, Oct. 20, 2013. (AP Photo/Fabrizio Giovannozzi)
Fiorentina's Giuseppe Rossi celebrates after scoring during a Serie A soccer match between Fiorentina and Juventus at the Artemio Franchi stadium in Florence, Italy, Sunday, Oct. 20, 2013. (AP Photo/Fabrizio Giovannozzi)
Paris Saint Germain's Zlatan Ibrahimovic, top, jumps in the air after scoring the second goal against Bastia, during the French League One soccer match between Paris Saint Germain and Bastia, at the Parc des Princes stadium, in Paris, Saturday, Oct. 19, 2013.(AP Photo/Remy de la Mauviniere)
AS Roma's Miralem Pjanic of Bosnia and Herzegovina scores on a penalty kick during a Serie A soccer match between AS Roma and Napoli at Rome's Olympic stadium, Friday, Oct. 18, 2013. (AP Photo/Gregorio Borgia)
LONDON (AP) — Giuseppe Rossi's hat trick for Fiorentina against Serie A champion Juventus earned him the top player vote in The Associated Press global soccer poll this week, while Roma remained first in the club rankings.
Rossi, the new leading scorer in Serie A with eight goals, inspired his team to an astonishing comeback from 2-0 down by scoring three times in 14 minutes.
"Juventus were leading 2-0 in Florence with less than half an hour to go when 'Pepito' stole the show and turned the game upside down," said Aurelio Capaldi of RAI Sport in Italy. "He scored a terrific treble and became the nightmare of Juventus defenders. It ended up 4-2 and Fiorentina celebrated an unforgettable day for them."
Rossi headed off second-placed Zlatan Ibrahimovic, who scored a pair for Paris Saint-Germain including an incredible back-heel flick, and third-placed Miralem Pjanic of Roma.
Pjanic scored both as his side beat second--placed Napoli 2-0 to stay top of Serie A with eight wins in eight games.
"The manner of Roma's victory on Friday evening against Napoli was almost as eye-opening as the gap it has allowed them to open at the summit of Serie A," said Richard Winton of The Herald in Scotland. "Rudi Garcia has his side playing some stunning football and to sweep aside a Champions League team in such a way was awesome."
English Premier League leader Arsenal polled second following its 4-1 demolition of Norwich.
Mesut Ozil scored twice for Arsenal and is fourth in the player vote by 25 global soccer writers, a rise of six places from the previous poll.
Ozil's Germany teammate, Thomas Mueller, was ninth after he scored twice in Bayern Munich's 4-1 comeback win over Mainz which gave the club fourth in the poll.
James Thorogood, editor of Bundesliga.com, cited Pep Guardiola's decision to introduce Mario Goetze at halftime with his team trailing 1-0 as a key moment in the game.
"It was the first time the Bavarians had fallen behind under head coach Pep Guardiola, yet the Spaniard's masterstroke to throw Goetze into the fray breathed new life into his side," Thorogood said.
Goetze is eighth in the poll.
Real Madrid polled seventh after its 2-0 home victory against Malaga. The win was particularly important as Barcelona and Atletico Madrid dropped points with a draw against Osasuna and a defeat against Espanyol respectively.
Real are third in La Liga, two points behind Atletico and three away from Barcelona.
Southampton polled 10th after its surprising start continued with a 1-1 draw against Manchester United at Old Trafford.
___
AP Global Soccer 10 rankings, week ending Oct. 22
Players:
1. Giuseppe Rossi, 192 points.
2. Zlatan Ibrahimovic, 147.
3. Miralem Pjanic, 143.
4. Mesut Ozil, 133.
5. Sergio Aguero, 80.
6. Edinson Cavani, 61.
(tie) Eden Hazard 61.
8. Mario Goetze, 60.
9. Thomas Mueller, 39.
10. Wilfredo Caballero, 37.
Teams:
1. Roma, 211.
2. Arsenal, 203.
3. Fiorentina, 177.
4. Bayern Munich, 148.
5. Paris Saint-Germain, 135.
6. Chelsea, 85.
7. Real Madrid, 65.
8. Manchester City, 50.
9. Espanyol, 45.
10. Southampton, 26.
Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-10-22-SOC-AP-Global-Soccer-10/id-53f89f5843254861944f7cd9536e0aaaCategory: Presidents Cup Streaker Why Did The Government Shut Down revenge powerball winning numbers Erwin Schrödinger
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